Abstract

Polycystic ovarian syndrome (PCOS) is the most common hormonal abnormality in reproductive age of women. The features of PCOS include increased androgen production and disordered gonadotropin secretion leading to menstrual irregularity and infertility. In addition, 40-80% of women with this condition are reported to be overweight or obese. In our study of 50 cases with closely matched age groups, we evaluated hormonal levels and non-endocrine factors like serum lipid peroxidation (LPO), superoxide dismutase (SOD), obesity and age. Alteration in hormones in different age groups (20-30, 31-40 and 41-50 years) was detected with changes in LPO and SOD levels comparatively. Similarly, obesity is an indicative of higher BMI values. These altered endocrine, oxidative stress and elevated BMI indicators are associated with this pathological condition. Among preventive measures/strategies, such cases are suggested to undergo regular exercises and promoting healthy lifestyles, based on diet on long term basis as effective therapies or to have metabolic surgery to restore fertility.



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