Cancer is a disease in which the cell grows and divides abnormally without respect to normal limit, invade and destroy and other tissue and in its most matured state metastasizes to other tissues in the various part of the body. In general the chance of getting a cancer tends to increase with age. Cancer results from the breakdown of regulator mechanisms that govern proliferation, differentiation and survival of individual cell. As a result of the loss of regulation, cancer cell grow and divide in an uncontrolled manner. They ultimately spread throughout the body, interfering with the functions of normal and organs. The generalized loss of growth control shown by cancer cells resulting in continual unregulated proliferation is the result of accumulated abnormalities. Gastric adenocarcinoma is a progressive disease that involves various distinct but overlapping stages. As gastric niches are highly proliferate marked with constant cellular turnover, tumors arising in this environment can be due to the accumulation of mutations in the progenitor or residual stem cells. Our study reveals expression pattern of ERBB2 and cyclin D1 in Normal, chronic gastritis, intestinal metaplasia, dysplasia and adenocarcinomatous tissues of the stomach.


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