Abstract

Neuroinflammation is a common protective mechanism in homeostasis breakdown processes on the central nervous system. The prolongation of this process is responsible for the primary immune response of many neurodegenerative diseases. Understand these mechanisms has brought more effective alternatives to the scientific literature, on development of more effective pharmacological interventions. However, allopathic means of intervention to inflammation are sometimes insufficient to promote a good prognosis and reversal of the inflammatory process. Resveratrol is a polyphenol from the stilbene class, that has shown anti-inflammatory characteristics in several disease study methods, mainly in the ability to generate neuroprotection in neuroinflammatory damage models, reducing the production of pro-inflammatory cytokines and allowing survival, as well. Neuronal regeneration activity also as saw mainly through neurotrophin modulation and antioxidant activity. Resveratrol has shown promise in reversing neuronal death, an important activity in the face of the special needs for new drugs, capable enough to promoting better survival for patients with neurodegenerative diseases. In this review, it’s possible saw that Resveratrol has significant characteristics for future use in the treatment of neurodegenerative diseases.