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Detection of Sole and Clonal Aneuploidy in Hematologic Malignant Diseases

Nidhi P. SHAH 1, 2
Parth S.SHAH 1, 3
Nirzary H.BHATT 1
Krishna MISTRY 1
Jeanny DOMINIC 1
Mudra KANSARA 1
Samiksha HAKIM 1
Sandip C. SHAH 1
Manadava V RAO 1, 4, *

  1. Neuberg Supratech Referral Laboratory, Ahmedabad-6, India
  2. Department of Pediatrics, Nassau University Medical Centre, New York City, New York, USA.
  3. Department of medicine, Lahey hospital and Medical centre, Boston, Massachusets USA
  4. School of sciences, Gujarat University, Ahmedabad, India
Correspondence to: Manadava V RAO, Neuberg Supratech Referral Laboratory, Ahmedabad-6, India; School of sciences, Gujarat University, Ahmedabad, India. Email: pvphuc@bmrat.org.
Volume & Issue: Vol. 5 No. 3 (2019) | Page No.: 6-21 |
Published: 2019-09-30

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Copyright © 2019 by the author(s).

Copyright The Author(s) 2017. This article is published with open access by BioMedPress. This article is distributed under the terms of the Creative Commons Attribution License (CC-BY 4.0) which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. 

Abstract

Numerical chromosomal aneuploidy has diagnostic and prognostic value in detection of cancer. Hence, the study was undertaken in leukemic cases in our diagnostic laboratory. Analysis of 211 leukemic blood samples from referral cases of Neuberg Supratech Referral Laboratory (NSRL), Ahmedabad, India, since 2017 to 2019 using WHO protocols for chromosomal study. Detection of 23 cases were obtained (23/ 211: 11%) with this condition. Trisomy 8, 11, 13, 21 and monosomy 7 contributed to 18 cases (18/ 23; 78%) with 5 clonal anomaly (5/23; 22%). Four clonal patients were +8, +21 and +21, XXY and -7 with XY cells. Another karyotype with 48,XY,+8,+19/ 47,XY,+8 was detected which seems to be a new cytogenetic anomaly in the literature causing haematologic neoplasms in this cohort.

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